What is CBDA? Differences & Benefits of CBD vs CBDA
If you consider taking a CBD oil supplement, you may wonder: What is CBDA? CBDA is a chemical derivative of the cannabis plant. It is available in all 50 states, but you should check your local laws before buying. Some states restrict the use of CBDA for sale, and others do not. Make sure that your CBD oil contains no THC to avoid legal issues.
CBDA is an acid
CBDA is an acid that has both a carboxyl and a hydroxyl group. It is a triterpene that is found naturally in plants and is known to have anti-inflammatory and anti-anxiety effects. The compound is currently being tested in clinical trials. Eventually, it could be available in tablets and topical applications.
CBDA is similar to common NSAIDs, including ibuprofen and acetaminophen. Because of this similarity, researchers are looking into whether CBDA works similarly. They have found that it inhibits the enzyme COX-2, which causes inflammation. CBDA is also more effective than THC for anti-nausea and anti-anxiety effects.
Research on CBDA has found that it has potential as a treatment for depression. It was able to improve levels of serotonin in rats. It may also improve sleep quality. It has also been found to interact with the body’s endocannabinoid system, also known as the ECS. This system consists of cannabinoid receptors and neurotransmitters that help regulate sleep, appetite, and homeostasis.
It inhibits COX-2
CBDA inhibits COX-2 in the body, but not COX-1, a key enzyme in the body’s response to injury and infection. COX-1, however, is crucial for protecting the stomach lining, and inhibiting it can increase the risk of gastrointestinal bleeding.
CBDA is a phenolic compound that inhibits COX-2. It is similar to the structure of nonsteroidal anti-inflammatory drugs. The chemical structure of CBDA makes it a selective COX-2 inhibitor. In a recent study, scientists discovered that CBDA inhibits COX-2 better than the psychoactive component THC, a chemical found in marijuana.
COX enzymes are present in all tissues and are responsible for housekeeping functions. COX-1 is found in most tissues, including the kidneys, and plays a role in normal cellular functions. COX-2 is expressed in response to pro-inflammatory stimuli in the kidney, brain, and reproductive tissues.
It increases serotonin production.
CBDA is a chemical that can affect the production of serotonin in the brain. Serotonin is a neurotransmitter that helps to signal between cells and is essential for maintaining a balanced mood and stress-free life. Serotonin levels in the brain decrease during stressors, such as chemotherapy and radiation, and higher serotonin levels can alleviate the effects of these treatments.
The body produces serotonin in the gastrointestinal tract and the brain. The enterochromaffin cells in the intestines produce around 90% of the serotonin in the body. Serotonin is also essential for controlling sleep cycles, learning and mood. Serotonin also plays a role in releasing melatonin, a hormone that helps regulate the body’s circadian rhythms.
It inhibits cancer cell growth.
The biologically active constituent of the cannabis plant, CBDA, is believed to inhibit the growth and migration of highly aggressive cancer cells. It works by activating a receptor called RhoA, which inhibits cancer cell movement. Moreover, the compound has an anti-tumour effect by inhibiting COX-2 and ERK signalling.
The antitumor activity of plant-derived and synthetic CBs is based on evidence from experimental animal models. However, some studies indicate that CBD may promote tumour progression. The relevant data are reviewed in the following chapters, including kinetic data for individual CBS. Detailed information about the biological activity of CBS is also summarized in Table 1.
In addition to its antitumor activity, CBDA also has various biological effects. It is an inhibitor of COX-2 and inhibits cell growth by blocking the activity of AKT. It also inhibits the epithelial-mesenchymal transition in cancer cells.
It inhibits breast cancer metastasis.
CBD inhibits breast cancer metastasis by modulating the tumour microenvironment and inhibiting cytokine production by tumour cells. Furthermore, it inhibits the invasion of tumour cells by total macrophages and M2 macrophages. These results indicate that CBD inhibits breast cancer metastasis in mice.
It has been shown that CBD inhibits the proliferation and metastasis of breast cancer cells by suppressing the EGF/EGFR signalling pathway and its downstream targets. This inhibition may be an effective antitumor target for future therapies. Additionally, CBD inhibits the EGF-induced cytokine secretion by cancer cells, inhibiting angiogenesis and macrophage recruitment. Therefore, CBD inhibits breast cancer metastasis and may be a novel antitumor drug.
CBD inhibits breast cancer metastasis by down-regulating ID1 and up-regulating ID2 in breast cancer cells. In addition, CBD induces programmed cell death in different cancer cells. However, its molecular mechanism and impact on the tumour microenvironment remain unclear.